Feb 24, 2015

«Metagenomic analysis of historical samples»


Dr. Neus Marí-Mena, project manager at AllGenetics, to present her work at the Universidade da Coruña next Thursday.

AllGenetics' project manager Dr. Neus Marí-Mena will present her work at the Faculty of Sciences of the Universidade da Coruña (Spain) next Thursday, February 26th. The talk, which summarises the work carried out by Dr. Marí-Mena at the Universitetet i Oslo, is entitled «Metagenomic analysis of historical samples».

Millions of DNA sequences from historical samples can be generated using genome-wide sequencing approaches. However, the data collected from museum samples does not only contain DNA from the organism of interest, but also from other sources, mainly derived from microbial contamination during the handling process. In this study, Dr. Marí-Mena and her co-workers processed shotgun sequencing data using a metagenomic pipeline in order to profile the microbial community composition of museum samples of the Atlantic cod (Gadus morhua). Subsequently, they analysed post-mortem DNA damage patterns to authenticate the microbial dataset as ancient, rather than as a product of modern contamination. This allowed researchers to investigate the impact of different preservation conditions on historical data and maximise the amount of information retrieved from a shotgun sequencing dataset.

Metagenomics has had a spectacular effect on the advance of Microbiology. This new approach, which is based on next-generation sequencing technologies, allows for the direct study of bacteria, viruses, and fungi regardless of their culturability. AllGenetics is most interested in metagenomic and DNA metabarcoding approaches because of their growing contribution to the development of areas such as ecology, biodiversity, and food control.

The talk will be held at the Faculty of Sciences on Thursday 26th February at 12 pm. Free admission.